代表性成果 （论文/专利/专著等） |
1. Sujuan Xua, Shizheng Huang, Zhilin Luan, Tingyue Chen, Yuanyi Wei, Miaomiao Xing, Yaqing Li, Chunxiu Du, Bing Wanga, Feng Zheng, Nanping Wang, Youfei Guan, Jan-Åke Gustafssond, and Xiaoyan Zhang*. Farnesoid X receptor is essential for the survival of renal medullary collecting duct cells under hypertonic stress. Proc Natl Acad Sci U S A . 2018 May 22;115(21):5600-5605. 2.Xu H, Du S, Fang B, Li C, Jia X, Zheng S, Wang S, Li Q, Su W, Wang N, Zheng F, Chen L, Zhang X, Gustafsson JÅ, Guan Y. VSMC-specific EP4 deletion exacerbates angiotensin II-induced aortic dissection by increasing vascular inflammation and blood pressure. Proc Natl Acad Sci U S A .2019 Apr 23;116(17):8457-8462. 3. Hu Xu#, Bingying Fang#, Shengnan Du#, Sailun Wang, Qingwei Li, Xiao Jia, Chengzhen Bao, Lan Ye, Xue Sui, Lei Qian, Zhilin Luan, Guangrui Yang, Feng Zheng, Nanping Wang, Lihong Chen*, Xiaoyan Zhang*, and Youfei Guan*. Endothelial cell prostaglandin E2 receptor EP4 is essential for blood pressure homeostasis. JCI Insight. 2020 Jul 9;5(13):e138505. 4. Zhilin Luan , Yuanyi Wei , Xiaoxiao Huo , Xiaowan Sun , Cong Zhang , Wenhua Ming , Zhaokang Luo, Chunxiu Du , Yaqing Li 2, Hu Xu , Heyuan Lu , Feng Zheng , Youfei Guan*, Xiaoyan Zhang*. Pregnane X receptor (PXR) protects against cisplatin-induced acute kidney injury in mice. Biochim Biophys Acta Mol Basis Dis. 2021 Mar 1;1867(3):165996. 5. Luan ZL, Ming WH, Sun XW, Zhang C, Zhou Y, Zheng F, Yang YL, Guan YF*, Zhang XY*. A naturally occurring FXR agonist, alisol B 23-acetate, protects against renal ischemia-reperfusion injury. Am J Physiol Renal Physiol. 2021 Nov 1;321(5):F617-F628. 6.Wen Su , Sijin Wu, Yongliang Yang , Yanlin Guo 5 , Haibo Zhang , Jie Su , Lei Chen , Zhuo Mao, Rongfeng Lan , Rong Cao , Chunjiong Wang , Hu Xu , Cong Zhang , Sha Li , Min Gao , Xiaocong Chen , Zhiyou Zheng , Bing Wang , Yi'ao Liu , Zuojun Liu , Zimei Wang , Baohua Liu , Xinmin Fan , Xiaoyan Zhang* , Youfei Guan*. Phosphorylation of 17β-hydroxysteroid dehydrogenase 13 at serine 33 attenuates nonalcoholic fatty liver disease in mice. Nat Commun. 2022 Nov 2;13(1):6577; 7.Chunxiu Du, Hu Xu, Cong Cao, Jiahui Cao, Yufei Zhang, Cong Zhang, Rongfang Qiao, Wenhua Ming , Yaqing Li, Huiwen Ren, Xiaohui Cui, Zhilin Luan, Youfei Guan*, Xiaoyan Zhang*. Neutral amino acid transporter SLC38A2 protects renal medulla from hyperosmolarity-induced ferroptosis. Elife. 2023 Feb 1;12:e80647; 8.Shen-Ming Huang, Meng-Yao Xiong , Lei Liu , Jianqiang Mu, Ming-Wei Wang, Ying-Li Jia , Kui Cai, Lu Tie , Chao Zhang, Sheng Cao, Xin Wen, Jia-Le Wang, Sheng-Chao Guo, Yu Li, Chang-Xiu Qu, Qing-Tao He , Bo-Yang Cai, Chenyang Xue, Shiyi Gan, Yihe Xie, Xin Cong, Zhao Yang , Wei Kong, Shuo Li, Zijian Li, Peng Xiao, Fan Yang , Xiao Yu, You-Fei Guan, Xiaoyan Zhang*, Zhongmin Liu*, Bao-Xue Yang*, Yang Du*, and Jin-Peng Sun*. Single hormone or synthetic agonist induces Gs/Gi coupling selectivity of EP receptors via distinct binding modes and propagating paths. Proc Natl Acad Sci U S A. 2023 July 21;120 (30) e2216329120； 9.Wen-Hua Ming, Zhi-Lin Luan, Yao Yao, Hang-Chi Liu, Shu-Yuan Hu, Chun-Xiu Du, Cong Zhang, Yi-Hang Zhao, Ying-Zhi Huang, Xiao-Wan Sun, Rong-Fang Qiao, Hu Xu, You-Fei Guan*, Xiao-Yan Zhang*. Pregnane X receptor activation alleviates renal fibrosis in mice via interacting with p53 and inhibiting the Wnt7a/β-catenin signaling. Acta Pharmacologica Sinica. 2023 Oct;44(10):2075-2090. 10.Hu Xu, Xiuhui Mao, Yali Wang, Chunhua Zhu, Bo Liang, Yihang Zhao, Mengfei Zhou, Lan Ye, Mengting Hong, Huishu Shao, Yashuo Wang, Haonan Li, Yinghui Qi, Yongliang Yang, Lihong Chen, Youfei Guan*, Xiaoyan Zhang*. Targeting E prostanoid receptor EP4 to treat cardiac fibrosis. Adv Sci (Weinh). 2025 Feb 7:e2413324. |
