代表性成果 （论文/专利/专著等） |
1.Wu J, Li S, Wang W, Li J, Chi Y, Kong X, Zhou Y, Yang J, Gustafsson JÅ, Guan Y*. Thyroid hormone-responsive spot 14 protein promotes hepatic lipogenesis, and its expression is regulated by liverX receptor a through a sterol regulatory element-binding protein 1c-dependent mechanism in mice. Hepatology 2013 Aug;58(2):617-28. 2.Zhang X, Huang S, Gao M, Liu J, Jia X, Du S, Han Q, Zheng S, Gustafsson JÅ, Guan Y*. Farnesoid X receptor (FXR) gene deficiency impairs urine concentration in mice. Proc Natl Acad SciU S A. 2014 Feb 11;111(6):2277-82. 3.Wang C, Chi Y, Li J, Li S, Su W, Jia S, Chen Z, Miao Y, Du S, Zhang X, Zhou Y, Wu W, Zhu M, Wang Z, Yang H, Xu G, Wang S, Yang J，Guan Y*. FAM3A activates PI3K p110a/Akt signaling to ameliorate hepatic gluconeogenesisand lipogenesis. Hepatology 2014;59:1779-90. 4.Su W, Wang Y, Jia X, Wu W, Li L, Tian X, Li S, Wang C, Xu H, Cao J, Han Q, Xu S, Chen Y, Zhong Y, Zhang X, Liu P, Gustafsson JÅ, Guan Y*. Comparative proteomic study reveals 17β-HSD13 as a pathogenic protein in nonalcoholic fatty liver disease. Proc Natl Acad Sci U S A. 2014 Aug 5;111(31):11437-42. 5.Gao M, Cao R, Du S, Jia X, Zheng S, Huang S, Han Q, Liu J, Zhang X, Miao Y, Kang J, Gustafsson JÅ, Guan Y*. Disruption of prostaglandin E2 receptor EP4 impairs urinary concentration via decreasing aquaporin 2 in renal collecting ducts. Proc Natl Acad Sci U S A. 2015 Jul 7;112(27):8397-402. 6.Xu H, Fu JL, Miao YF, Wang CJ, Han QF, Li S, Huang SZ, Du SN, Qiu YX, Yang JC, Gustafsson JA, Breyer RM, Zheng F, Wang NP, Zhang XY, Guan Y*. Prostaglandin E2 receptor EP3 regulates both adipogenesis and lipolysis in mouse white adipose tissue. J Mol Cell Biol. 2016 Dec;8(6):518-29. 7.Su W, Peng J, Li S, Dai YB, Wang CJ, Xu H, Gao M, Ruan XZ, Gustafsson JA, Zhang XY, Guan Y*. Liver X receptorαinduces 17β-hydroxysteroid dehydrogenase-13 expression through SREBP-1c. Am J Physiol Endocrinol Metab. 2017 Apr 1;312(4):E357-E367. 8.Zhang X, Li S, Zhou Y, Su W, Ruan X, Wang B, Zheng F, Warner M, Gustafsson JÅ, Guan Y*. Ablation of cytochrome P450 omega-hydroxylase 4A14 gene attenuates hepatic steatosis and fibrosis. Proc Natl Acad Sci U S A. 2017 Mar 21;114(12):3181-3185. 9. Xu S, Huang S, Luan Z, Chen T, Wei Y, Xing M1, Li Y, Du C, Wang B, Zheng F, Wang N, Guan Y, Gustafsson JÅ, Zhang X. Farnesoid X receptor is essential for the survival of renal medullary collecting duct cells under hypertonic stress. Proc Natl Acad Sci U S A. 2018 May 22. 115(21):5600-5605. 10. Chunxiu Du, Hu Xu, Cong Cao, Jiahui Cao, Yufei Zhang, Cong Zhang, Rongfang Qiao, Wenhua Ming, Yaqing Li, Huiwen Ren, Xiaohui Cui, Zhilin Luan, Youfei Guan *, Xiaoyan Zhang *. Neutral amino acid transporter SLC38A2 protects renal medulla from hyperosmolarity-induced ferroptosis. eLife. 2023 Feb 1;12:e80647. 11. Wen-Hua Ming, Zhi-Lin Luan, Yao Yao, Hang-Chi Liu, Shu-Yuan Hu, Chun-Xiu Du, Cong Zhang, Yi-Hang Zhao, Ying-Zhi Huang, Xiao-Wan Sun, Rong-Fang Qiao, Hu Xu, You-Fei Guan, Xiao-Yan Zhang.Pregnane X receptor activation alleviates renal fibrosis in mice via interacting with p53 and inhibiting the Wnt7a/beta-catenin signaling. Acta pharmacologica Sinica. 2023 Jun 21.44(10):2075-2090. 11.Haibo Zhang,Jiazhen Chang,Zhihong Dai,Qiuming Wang,Rongfang Qiao,Yingzhi Huang,Beibei Ma,Jiuchao Jiang,Chunhua Zhu,Wen Su,Xiaoyan Zhang,Youfei Guan.Expression and localization of HSD17B13 along mouse urinary tract.Am J Physiol Renal Physiol.2024 Jul 1;327(1):F146-F157. 12.Hu Xu, Xiuhui Mao, Yali Wang, Chunhua Zhu, Bo Liang, Yihang Zhao, Mengfei Zhou, Lan Ye, Mengting Hong, Huishu Shao, Yashuo Wang, Haonan Li, Yinghui Qi, Yongliang Yang, Lihong Chen, Youfei Guan*, Xiaoyan Zhang*. Targeting E prostanoid receptor EP4 to treat cardiac fibrosis. Adv Sci (Weinh). 2025 Feb 7:e2413324. |
